臨床大視場x線多襯度肺成像原型機

簡介

通過將三個吸收光柵與一個醫(yī)用X射線管和一個醫(yī)用平板探測器集成在一起，該工作開發(fā)了具有高達40×50 cm2大視場的臨床X射線多襯度肺部成像原型。除了傳統(tǒng)的 X 射線吸收成像外，原型系統(tǒng)還同時提供相位襯度和暗場圖像。與傳統(tǒng)的基于光柵的相襯成像 (GPCI) 系統(tǒng)不同，掃描對象放置在圖案生成光柵 G1 的后面，將輻射劑量降低到可能是原始系統(tǒng)設計的一半。對于快速掃描過程，使用了三個大視場的吸收光柵。此外，X射線管、三個光柵和探測器都固定在同一機械臂上，沿垂直方向掃描物體。開發(fā)了一個數(shù)值模擬平臺來幫助優(yōu)化成像參數(shù)。最后，通過全身麻醉兔的初步實驗結果證明了多襯度原型系統(tǒng)的能力，其暗場圖像能夠為肺部疾病的診斷提供額外的診斷價值。可以在該原型系統(tǒng)上進一步直接評估多襯度肺部成像的潛在臨床統(tǒng)一性。

關鍵詞：基于光柵的X射線成像；肺成像；大視野。

A preclinical large-field-of-view x-ray multi-contrast lung imaging prototype

Abstract

By integrating three absorption gratings with a medical X-ray tube and a medical flat panel detector, a preclinical X-ray multi-contrast lung imaging prototype with a large field-of-view up to 40 × 50 cm2 was developed in this work. The prototype system provides phase-contrast and dark-field images simultaneously in addition to the conventional X-ray absorption imaging. Unlike the traditional grating-based phase-contrast imaging (GPCI) system, the scanning object is placed behind the pattern-generating grating G1, reducing the radiation dose to probably half of the original system design. For a fast scan process, three absorption gratings inducing a large field-of-view were utilized. Besides, the X-ray tube, the three gratings and the detector are all fixed on the same mechanical arm, scanning the object along the vertical direction. A numerical simulation platform was developed to help optimize the imaging parameters. Finally, the preliminary experimental results of a full-body enthanized rabbit demonstrate the capability of the multi-contrast prototype system, and its dark-field images are capable of providing additional diagnostic value for the diagnosis of lung diseases. Direct evaluation of the potential clinical unity of the multi-contrast lung imaging can be further performed on this prototype system.

Keywords: Grating-based X-ray imaging; Lung imaging; Large field-of-view.

文章鏈接：Li, Xinbin, et al. "A preclinical large-field-of-view x-ray multi-contrast lung imaging prototype." Medical Imaging 2020: Physics of Medical Imaging. Vol. 11312. SPIE, 2020.

文章中所使用的光柵是由德國Microworks生產(chǎn)定制、生產(chǎn)的（點擊了解詳情）。光柵具體參數(shù)如下：